Anti-Granzyme B (NK/T-Cell Lymphoma Marker), Monoclonal Antibody
| Product Name | Anti-Granzyme B (NK/T-Cell Lymphoma Marker), Monoclonal Antibody |
|---|---|
| Description | Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'non-self' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin_Ûªs Disease. |
| Synonyms | Cathepsin G-like 1, CCPI, CGL1, CSPB, CTLA-1, CTSGL1, Cytotoxic serine protease B, Cytotoxic T lymphocyte associated serine esterase 1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, Granzyme B, Granzyme-2, GRB, Gzmb, Human lymphocyte protein (Hlp), Lymphocyte protease, SECT, T-cell serine protease 1-3E |
| Host | Rabbit |
| Clonality | Monoclonal |
| Immunogen | Recombinant fragment (115 Amino acid residues; aa 73-187) of human Granzyme B protein |
| Isotype | IgG |
| Reactivity | Human |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml. |
| Gene Id | 3002 |
| Uniprot | P10144 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Shresta, S., et al. 1995. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc. Natl. Acad. Sci. USA 92: 5679-5683 |
| Supplier | ARP |
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