| Product Name | Anti-GTF2IRD2 Antibody [PCRP-GTF2IRD2-1B12] |
|---|---|
| Description | Mouse monoclonal [PCRP-GTF2IRD2-1B12] antibody to GTF2IRD2. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-GTF2IRD2-1B12 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human GTF2IRD2 protein. |
| Isotype | IgG2b |
| Molecular Weight | 107 kDa |
| Target | GTF2IRD2 |
| Specificity | The TFII-I family contains two highly homologous 949 amino acid proteins, GTF2IRD2 (GTF2I repeat domain containing 2) and GTF2IRD2B (general transcription factor II-I repeat domain-containing protein 2B). Localizing to the nucleus, these proteins are ubiquitously expressed and contain two GTF2I- like repeats. Encoded by a gene mapping to human chromosome 7q11.23, GTF2IRD2 and GTF2IRD2B are located in the Williams-Beuren syndrome (WBS) critical region. The deletion of genes located within this region results in WBS, possibly due to the unequal crossing over of highly homologous low-copy repeat sequences that flank the deleted region. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits including facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities. |
| Reactivity | Human |
| Applications | FC, WB |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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