Anti-HCG-beta (Pregnancy & Choriocarcinoma Marker), Monoclonal Antibody
| Product Name | Anti-HCG-beta (Pregnancy & Choriocarcinoma Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody reacts with a protein of 22kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the ? and ? subunits. The ? subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG monoclonal antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior. |
| Synonyms | CG-beta, CGB3, CGB5, CGB7, CGB8, Choriogonadotropin Subunit beta, hCGB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPM529 |
| Immunogen | Recombinant hCG beta protein |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 1082 |
| Uniprot | P01233 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Cocquebert M et. al. Am J Physiol Endocrinol Metab. 2012;303(8):E950-8 |
| Supplier | ARP |
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