Anti-Heparan Sulfate Proteoglycan (Large) / Perlecan, Monoclonal Antibody
| Product Name | Anti-Heparan Sulfate Proteoglycan (Large) / Perlecan, Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. |
| Synonyms | Heparan sulfate proteoglycan of basement membrane, HSPG, Hspg2, LG3 peptide, Perlecan, PLC, SJS1 |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | A7L6 |
| Immunogen | Murine EHS laminin preparation |
| Isotype | IgG2a, kappa |
| Reactivity | Bovine, Fish, Human, Mouse, Porcine, Primate |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml. |
| Gene Id | 3339 |
| Uniprot | P98160 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Folkvord et. al., J Histochem Cytochem, 1989; 37:105-113.Couchman et. al., Matrix, 1989; 9:311-321.Horiguchi et. al., J Histochem Cytochem, 1989; 37:961-970.Ljubimov et. al., Int J Cancer, 1992; 50:562-566.Guelstein et. al., Int J Cancer, 1993; 53:269-277.Ljubimov et. al., Lab Invest, 1995; 72:461-473 |
| Supplier | ARP |
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