| Product Name | Anti-HER-2 / c-erbB-2 / neu / CD340, Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This monoclonal antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. |
| Synonyms | p185, CD340, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HRB2/282 |
| Immunogen | Recombinant extracellular domain of human HER-2 protein |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 2064 |
| Uniprot | P04626 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Utrilla JC, et al. Histopathology. 34: 60Ð65 (1999).Wright C, et al. British Journal of Cancer. 65: 118Ð121 (1992).Corbett IP, et al. Journal of Pathology. 161: 15Ð25 (1990) |
| Supplier | ARP |
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