| Product Name | Anti-HLA-A (MHC I), Monoclonal Antibody |
|---|---|
| Description | HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This monoclonal antibody is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and ðAw33). Its epitope maps between aa65-to-aa80 of the ?1 domain of the HLA-A. This monoclonal antibody recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant. |
| Synonyms | HLA-A, HLA class 1A, MHC class I HLA-A |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 108-2C5 |
| Immunogen | Normal human peripheral blood lymphocytes |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3105 |
| Uniprot | P01889; P30443; P30499 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Domenech N et al. Hum Immunol 1991, 30(2):140-6Lozano F et al. Immunogenetics 1989, 30::50-3Lozano F et al. Tissue Antigens 1990, 35:193-5Young NT et al. Hum Immunol 1997, 52(1):1-11Krensky AM et al Transplant Proc 1996, 28(6):3026-8Hansen JA et al Hematol Oncol Clin North Am 1990, 4(3):507-515 |
| Supplier | ARP |
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