| Product Name | Anti-HLA Class II DRB1 Antibody [rHLA-DRB/7198] |
|---|---|
| Description | Recombinant mouse monoclonal [rHLA-DRB/7198] antibody to HLA Class II DRB1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | rHLA-DRB/7198 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human HLA-DRB1 protein. |
| Isotype | IgG1 |
| Molecular Weight | 28 kDa (beta chain) |
| Target | HLA Class II DRB1 |
| Specificity | This MAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. s respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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