| Product Name | Anti-HLA DR Antibody [HLA-DRA/8287R] - BSA and Azide free |
|---|---|
| Description | Recombinant rabbit monoclonal [HLA-DRA/8287R] antibody to HLA DR. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | HLA-DRA/8287R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 1-200) of human HLA-DR protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | ~28 kDa (beta chain) |
| Target | HLA DR |
| Specificity | This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. s respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. |
| Reactivity | Human |
| Applications | IHC |
| Working Dilutions | IHC: (Frozen & Formalin-fixed) 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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