Anti-HPRT (clone AT2G8)

Antibodies, Monoclonal Antibodies
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Product Name Anti-HPRT (clone AT2G8)
Description HPRT is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. HPRT, which acts as a catalyst in the reaction between guanine and phosphoribosyl pyrophosphate to form GMP, functions primarily to salvage purines from degraded DNA to renewed purine synthesis.
Reactivity Human
Applications Dot blot, ELISA, WB
Clone AT2G8. Anti-human HPRT mAb, clone AT2G8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human HPRT protein.
Concentration 0.1 mg/ml
Form Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Species Mouse
Host Mouse
Isotype IgG1, K
Immunogen Recombinant human HPRT (1-218aa) purified from E. coli
Interest Fields Signal Transduction
NCBI Number NP_000185
References Sculley DG, et al. (1993). Hum. Genet. 90 (3): 195-207. Stout JT, Caskey CT (1986). Annu. Rev. Genet. 19: 127-48. Davidson BL, et al. (1991). Am. J. Hum. Genet. 48 (5): 951-8.
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Synonyms HGPRT, HGPRTase, HPRT, Hypoxanthine-guanine phosphoribosyltransferase HPRT 1, HPRT1, Hypoxanthine guanine phosphoribosyltransferase, Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome), Hypoxanthine phosphoribosyltransferase 1.
Working Dilutions Optimal dilution should be performed by user.

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