| Product Name | Anti-HPV16 E1 + E4 Antibody [HPV16 E1/E4] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [HPV16 E1/E4] antibody to HPV16 E1 + E4. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HPV16 E1/E4 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 36-41, of human HPV16 E1/E4. |
| Isotype | IgG1 |
| Molecular Weight | 16 kDa |
| Target | HPV16 E1 + E4 |
| Specificity | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse. |
| Reactivity | Virus |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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