| Product Name | Anti-HPV17 E7 Antibody [718-15] |
|---|---|
| Description | Mouse monoclonal [718-15] antibody to HPV17 E7. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 718-15 |
| Conjugate | Unconjugated |
| Immunogen | Oncoprotein E7 from human papillomavirus 18. |
| Isotype | IgG1 |
| Target | HPV17 E7 |
| Specificity | This antibody recognises the E7 oncoprotein of human papilloma virus 18. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. Mouse anti Human Papillomavirus 18 Oncoprotein E7 antibody, clone 718-15 does not cross-react with the E7 protein of HPV-16. |
| Reactivity | Virus |
| Applications | ELISA, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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