| Product Name | Anti-Hrk Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Hrk. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | A peptide corresponding to 15 amino acids from near the centre of human HRK (NP_003797). |
| Isotype | IgG |
| Molecular Weight | Approximately 13 kDa in mouse pancreas tissue lysate. |
| Target | Hrk |
| Protein Length | 15 |
| Specificity | This antibody recognises Harakiri (HRK), also known as Neuronal death protein DP5 or BH3-interacting domain-containing protein 3. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation.Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight of ~18 kDa, HRK often migrates at ~12-15 kDa. |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Working Dilutions | WB: 2 - 5 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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