| Product Name | Anti-HSP90 alpha Antibody [HSP90AA1/7247] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [HSP90AA1/7247] antibody to HSP90 alpha. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HSP90AA1/7247 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 500-700) of human HSP90AA1 protein. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 90 kDa |
| Target | HSP90 alpha |
| Specificity | The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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