Anti-human Growth Hormone (HGH) Polyclonal Antibody

Category: Antibodies
Catalog
03-11181A
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Product Name Anti-human Growth Hormone (HGH) Polyclonal Antibody
Description The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Synonyms GH, GHN, GH-N, hGH-N, IGHD1B
Clonality Polyclonal
Immunogen Human growth hormone
Specificity Human growth Hormone
Reactivity Human, Porcine
Applications IHC
Form Serum containing 0.1% sodium azide
Storage 2-8C for immediate use, or at -2°C (aliquot)
Background The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Supplier ARP

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