| Product Name | Anti-Human IgD Antibody [IGHD/2730R] |
|---|---|
| Description | Recombinant rabbit monoclonal [IGHD/2730R] antibody to Human IgD. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | IGHD/2730R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human IGHD protein. |
| Isotype | IgG |
| Molecular Weight | 44-80 kDa (heavy chain) / 21-25 kDa (kappa light chain) |
| Target | Human IgD |
| Specificity | Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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