Anti-Human Prostate Specific Antigen (PSA) Monoclonal Antibody
| Product Name | Anti-Human Prostate Specific Antigen (PSA) Monoclonal Antibody |
|---|---|
| Description | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. The presence of prostate specific antigen is highly specific for demonstration of the prostatic origin of a malignancy. |
| Synonyms | APS, PSA, hK3, KLK2A1 |
| Clonality | Monoclonal |
| Clone | ER-PR8 |
| Immunogen | Isolated from human prostatic carcinoma |
| Isotype | IgG1 |
| Specificity | Mab ER-PR8 has been shown to be a valuable reagent for the identification of primary and metastatic prostatic carcinoma. The antibody reacts with a 34kD protein in benign and malignant prostatic epithelium. |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Stabilized ascites containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Gallee MPW et al. (1990) Urological Research 18: 181-187 |
| Background | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. |
| Supplier | ARP |
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