| Product Name | Anti-iASPP Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to iASPP. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids 780-797 of human iASPP (isoform 1) protein. |
| Isotype | IgG |
| Molecular Weight | Approximately 100 and 50 kDa corresponding to iASPP isoforms 1 and 2 respectively. |
| Target | iASPP |
| Amino Acid Sequence | REGESVTVLRRDGPEETD |
| Protein Length | 18 |
| Specificity | This antibody recognises human inhibitor of apoptosis stimulating protein of p53 (iASPP), which plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is thought to encode three isoforms; isoform 1 is predominantly located in the cytoplasm, whilst isoforms 2 and 3 are nuclear proteins. iASPP is highly expressed in the heart, placenta and prostate.iASPP has been shown to have oncogenic properties in human breast carcinomas. |
| Reactivity | Canine, Human, Mouse |
| Applications | ELISA, IHC-P, WB |
| Working Dilutions | ELISA: 1:40,000 - 1:160,000, WB: 1:1,000 - 1:5,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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