| Product Name | Anti-ICAM-3 (CD50) Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. CD50 is a single chain polypeptide with a MW of 120 kD. The protein is heavily glycosylated and resistant to treatment with phosphatidylinositol phospholipase C, and therefore probably not PI-anchored to the membrane. The antibody was provisionally clustered as CDw50 in Vienna at the IV and as CD50 in Boston at the V international workshop on human leucocyte differentiation antigens. |
| Synonyms | CD50, CDW50, ICAM-R |
| Clonality | Monoclonal |
| Clone | 101-1D2 |
| Immunogen | Isolated from human leucocytes |
| Isotype | IgG1 |
| Specificity | The antibody reacts with the cellular adhesion molecule CD50 (ICAM-3) |
| Reactivity | Human |
| Applications | ICC, IHC |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Vilella, R. et al. (1990) Tissue Antigens 36: 203-210Knapp, W. et al. (1989) Leucocyte Typing IV, Oxford Univ. Press, pp 541, 667-670, 1087Schlossman, et al. (1993) Leucocyte Typing V, Oxford Univ. Press, pp 1546-1547, 2011Pino-Otin, MR et al. (1995) J Immunol 154: 3015-3024 |
| Background | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. |
| Supplier | ARP |
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