| Product Name | Anti-ICT1 (clone AT1E9) |
|---|---|
| Description | Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas. |
| Synonyms | Peptidyl-tRNA hydrolase ICT1, mitochondrial, DS-1, DS1 |
| Host | Mouse |
| Clone | AT1E9. Anti-human ICT1 mAb, clone AT1E9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ICT1 protein. |
| Immunogen | Recombinant human ICT1 (30-206aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Richer, R, et al. (2010) EMBO J 17;29(6): 1116-25van Belzen, N., et al. (1995) Eur J Biochem 15;234(3):843-8. |
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