| Product Name | Anti-IL-16 (clone J2F10) |
|---|---|
| Description | Interleukin-16 (IL-16) is an immunomodulatory cytokine, which induces lymphocyte migration, expression of proinflammatory IL-1beta, IL6 and tumour necrosis factor-alpha (TNFalpha), and modulates apoptosis. This protein is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. Also, IL-16 has been shown to recruit and activate many other cell including monocytes, eosinophils, and dendritic cells expressing the CD4 molecules. |
| Synonyms | LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289, IL 16, Lymphocyte chemoattractant factor, HGNC:5980, Interleukin 16 precursor, PrIL16, |
| Host | Mouse |
| Clone | J2F10. Anti-human IL-16 mAb, clone J2F10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-16 protein. |
| Immunogen | Recombinant human IL-16 (502-631aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Bernstein HB., et al. (2006) J Immunol. 15; 177(6):3669-76. McFadden C J., et al. (2007) J Immunol. 15; 179(10):6439-45. Cruikshank WW, et al. (2000) J Leukoc Biol 67:757-66. Center DM, et al. (2000) Immunol Today. (6):273-80. |
| Supplier | ARP |
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