| Product Name | Anti-IL-2 (clone AT2D5) |
|---|---|
| Description | IL-2 (Interleukin 2) is 153 amino acid protein. IL-2 produced by T cells in response to antigenic or mitogenic stimulation. This protein is required for T cell proliferation and other activities crucial to regulation of the immune response. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. Three different IL-2 dependent signal transduction pathways have been identified: the c-Fos/c-Jun induction pathway mediated by Src family protein-tyrosine kinases; the c-Myc induction pathway; and the Rapamycin-sensitive pathway. |
| Synonyms | IL-2, TCGF, Aldesleukin, T-cell growth factor, Interleukin-2, IL2, interleukin 2 |
| Host | Mouse |
| Clone | AT2D5. Anti-human IL-2 mAb, clone AT2D5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-2 protein. |
| Immunogen | Recombinant human IL-2 (22-153aa) purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Smith, K.A., et al. (1980) J Exp Med 151(6): 1551€“6Smith, K.A., et al. (1983) J Immunol 131(4): 1808€“15Gordon, J., et al. (1965) Nature 208(5012): 795€“6 |
| Supplier | ARP |
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