| Product Name | Anti-IL-23 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to IL-23. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | A peptide corresponding to 16 amino acids from near the N-terminus of human IL-23. |
| Isotype | IgG |
| Molecular Weight | Approximately 24 kDa in mouse pancreas tissue lysate. |
| Target | IL-23 |
| Protein Length | 16 |
| Specificity | This antibody recognises the N-terminal domain of human interleukin-23 (IL-23), a ~21 kDa heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis. |
| Reactivity | Human, Mouse |
| Applications | WB |
| Working Dilutions | WB: 1 - 2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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