| Product Name | Anti-IL-31 Antibody [A01-1E4/A09.2-2E6] |
|---|---|
| Description | Mouse monoclonal [A01-1E4/A09.2-2E6] antibody to IL-31. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | A01-1E4/A09.2-2E6 |
| Conjugate | Unconjugated |
| Immunogen | E. coli derived recombinant human full length interleukin-31 (Ser24-Thr164). |
| Isotype | IgG1 |
| Target | IL-31 |
| Specificity | This antibody recognises interleukin-31 (IL-31), a member of the gp130/IL-6 family of proteins. It is a cytokine that has pro-inflammatory properties. IL-31 is mainly produced by CD4+ T helper and mast cells. IL-31 acts upon both immune and non-immune cells, regulating signaling of pro-inflammatory cytokines, cell proliferation and tissue remodeling. The effect of IL-31 is mediated by its receptor IL-31RA. Upon binding to this receptor, the JAK/STAT, PI3K/AKT and MAPK pathways can be activated. IL-31 has been implicated in chronic inflammation, with elevated levels detected in various skin diseases, Crohn’s disease and ulcerative colitis. Higher IL-31 levels in serum have also been positively correlated with asthma severity. The purified Mouse anti Human interleukin-31 antibody, clone A01-1E4/A09.2-2E6 (MCA6246GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-31 antibody, clone A12-2F7 (MCA6247B) as the detection antibody. |
| Reactivity | Human |
| Applications | ELISA |
| Working Dilutions | ELISA: 1 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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