| Product Name | Anti-IL-7 Antibody [IL7/4013] |
|---|---|
| Description | Mouse monoclonal [IL7/4013] antibody to IL-7. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | IL7/4013 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 27-177, corresponding to mature human IL-7. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 25 kDa |
| Target | IL-7 |
| Specificity | Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS. |
| Reactivity | Human |
| Applications | FC, IF, IHC-P |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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