| Product Name | Anti-IL12B (clone AT1D6) |
|---|---|
| Description | IL-12 is a heterodimer composed of subunits IL-12A p35 and IL-12B p40. Autocrine IL-12 is responsible for the differentiation of naive CD4+T cells into type 1 helper T cells (Th1) that produce interferon-gamma (IFN-gamma). Expression of STAT 4, a signal transduction molecule important in cytokine-induced gene expression, appears central to IL-12 induced Th1 production of IFN-gamma. It also activates production of tumor necrosis factor alpha (TNFalpha) from T and natural killer cells. IL-12 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Synonyms | Interleukin 12B precursor,interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), CLMF, IL-12B, NKSF, CLMF2, natural killer cell stimulatory factor-2, cytotoxic lymphocyte maturation factor 2 p 40, interleukin 12 p40, natural killer cell stimulatory factor 40 kD subunit, interleukin-12 beta chain, IL12 subunit p40, |
| Host | Mouse |
| Clone | AT1D6. Anti-human IL12B mAb, clone AT1D6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL12B protein. |
| Immunogen | Recombinant human IL12B (23-328aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | korman BD, et al., (2008) Curr Allergy Asthma Rep. 8(5):398-403 Holscher C., (2004) Med Microbiol Immunol. 193(1):1-17 |
| Supplier | ARP |
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