| Product Name | Anti-IL2 Polyclonal Antibody |
|---|---|
| Description | IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation. IL-2 also promotes peripheral development of Treg cells. Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells. The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2R_, IL-2R_ and the common gamma chain, _c. IL-2 R_ binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2R_ and _c subunits. IL-2R_ is also used by IL-15. The common _c is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21. Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways. |
| Host | Rabbit |
| Immunogen | Recombinant protein of human IL2 |
| Isotype | IgG |
| Reactivity | Human |
| Applications | ELISA, ICC, IHC, WB |
| Form | Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| Storage | Store at -20C or -80C. Avoid repeated freeze/thaw cycles. |
| Background | IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation. IL-2 also promotes peripheral development of Treg cells. Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells. The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2R_, IL-2R_ and the common gamma chain, _c. IL-2 R_ binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2R_ and _c subunits. IL-2R_ is also used by IL-15. The common _c is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21. Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways. |
| Supplier | Cusabio |
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