Anti-IL2 Receptor alpha Antibody [IL2RA/423] - BSA and Azide free
| Product Name | Anti-IL2 Receptor alpha Antibody [IL2RA/423] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [IL2RA/423] antibody to IL2 Receptor alpha. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | IL2RA/423 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human IL2RA protein. |
| Isotype | IgG2a |
| Molecular Weight | 55 kDa |
| Target | IL2 Receptor alpha |
| Specificity | This antibody recognizes a protein of 55kDa, identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkins disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R chain, p75) and CD132 (common chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This antibody recognizes the epitope B, which is located at residue 3-104 of CD25 and doe not block IL-2 binding to CD25. |
| Reactivity | Human |
| Applications | FC, Functional Studies, IF |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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