| Product Name | Anti-Insulin Polyclonal Antibody |
|---|---|
| Description | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. |
| Synonyms | INS, ILPR, IRDN, IDDM2, MODY10 |
| Clonality | Polyclonal |
| Immunogen | Porcine Insulin (Novo) |
| Specificity | Insulin |
| Reactivity | Ferret, Human, Porcine, Rat |
| Applications | IHC |
| Form | Serum containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Ahren B et al. (1989) Cell Tissue Res 256: 159-166Luts A et al. (1989) Cell Tissue Res 258: 259-267 |
| Background | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. |
| Supplier | ARP |
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