| Product Name | Anti-Integrin alpha V Antibody [RMV-7] - BSA and Azide free |
|---|---|
| Description | Rat monoclonal [RMV-7] antibody to Integrin alpha V. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | RMV-7 |
| Conjugate | Unconjugated |
| Immunogen | Cultured LAK cells from Balb/c mice. |
| Isotype | IgG1 |
| Target | Integrin alpha V |
| Specificity | This antibody recognises mouse CD51, a ~140 kDa alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61.Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing.Rat anti Mouse CD51 antibody, clone RMV-7 has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity. |
| Reactivity | Mouse |
| Applications | FA, FC, IP |
| Working Dilutions | Flow Cytometry: 1:10 for 0.1 mg, 1:25 for 0.25 mg, IHC-Fr: 1:25 - 1:100, Use 10µl of the suggested working dilution to label 106 cells in 100µl. |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline. |
| Concentration | 1 mg/ml |
| Storage | Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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