| Product Name | Anti-Integrin alpha 5 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Integrin alpha 5. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 750-1000 of human CD49e. |
| Isotype | IgG |
| Molecular Weight | Approximately 135 kDa in various cell and tissue lysates under reducing conditions |
| Target | Integrin alpha 5 |
| Amino Acid Sequence | TVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLW |
| Protein Length | 251 |
| Specificity | This antibody recognises CD49 antigen-like family member E, also known as integrin alpha-5 (ITGA5), integrin alpha-F and VLA-5. It belongs to the family of cell surface receptors and mediates signal transduction. CD49e was shown to regulate proliferation and adipogenic differentiation of human adipose derived stem cells. MicroRNA-205 (miR-205) down-regulates CD49e and this impairs triple negative breast cancer cell metastatic traits by inhibiting the Src/Vav2/Rac1 pathway. |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Working Dilutions | WB: 1:500 - 1:2,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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