| Product Name | Anti-Integrin beta 4 Antibody [UM-A9] |
|---|---|
| Description | Mouse monoclonal [UM-A9] antibody to Integrin beta 4. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | UM-A9 |
| Conjugate | Unconjugated |
| Immunogen | Human squamous cell carcinoma (UM-SCC1). |
| Isotype | IgG2a |
| Molecular Weight | 205 kDa |
| Target | Integrin beta 4 |
| Specificity | This antibody recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Reactivity | Human |
| Applications | Blocking, FC, IF |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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