| Product Name | Anti-Integrin beta 2 Antibody [BAQ30A] |
|---|---|
| Description | Mouse monoclonal [BAQ30A] antibody to Integrin beta 2. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BAQ30A |
| Conjugate | Unconjugated |
| Immunogen | Cells from multiple species. |
| Isotype | IgG1 |
| Target | Integrin beta 2 |
| Specificity | This antibody recognises bovine CD18 also known as ITGB2 or integrin beta-2. CD18 is a receptor for ICAM1, ICAM2, ICAM3, and ICAM4. It recognises the G-P-R motif in the fibrinogen alpha chain and is involved in leukocyte adhesion as well as transmigration of T cells and neutrophils. Different from other organisms, the signal peptide of ruminant CD18, the beta subunit, is not cleaved and remains intact on the mature CD18 molecule, leukotoxin from Pasteurella haemolytica binds to the intact signal peptide on ruminant leukocytes causing acute inflammation and lung damage. Holstein cattle harbor a mutation in CD18 causing bovine leukocyte adhesion deficiency (BLAD) syndrome with decreased expression of beta 2 integrins and lowered susceptibility to cytolysis in Pasteurella infections. |
| Reactivity | Camelus, Bison, Buffalo, Bovine, Canine, Feline, Goat, Human, Sheep |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in serum free tissue culture medium containing proprietary protein free supplement and 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Store at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
