| Product Name | Anti-Integrin beta 3 Antibody [HM beta 3.1] (PE) |
|---|---|
| Description | Hamster monoclonal [HM beta 3.1] antibody to Integrin beta 3 (PE). |
| Host | Hamster |
| Clonality | Monoclonal |
| Clone | HM beta 3.1 |
| Conjugate | PE |
| Immunogen | Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4. |
| Isotype | IgG |
| Target | Integrin beta 3 |
| Specificity | This antibody recognises the murine integrin beta 3 subunit (CD61), a ~90 kDa a type I membrane protein, expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.Hamster anti Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin. |
| Reactivity | Mouse, Rat |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 106 cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B). |
| Form | Lyophilized |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide. |
| Concentration | Reconstitution dependent. |
| Storage | Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. |
| Supplier | Antibodies.com |
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