| Product Name | Anti-Keratin K10 Polyclonal Antibody |
|---|---|
| Description | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. |
| Synonyms | KRT10, BIE, EHK, K10, KPP, BCIE, CK10 |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human keratin K10 (formerly alsodesignated cytokeratin 10; C-GS VGE SSS KGP RY), coupledto KLH |
| Specificity | MW 56,5000 (pI 5.3) intermediate filament polypeptide, keratin K10, detected by immunohistochemistry in the suprabasal layers of human epidermis (basal cells are negative). Useful for the recognition of keratinizing cells in squamous cell carcinoma of epidermis, lung, bladder, cervix, esophagus etc. Completely negative on non-stratified epithelia. |
| Reactivity | Human, Mouse, Rat |
| Applications | IF, IHC |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Langbein L et al. (2006) J Invest Dermatol 126: 2377-2386 |
| Background | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. |
| Supplier | ARP |
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