| Product Name | Anti-Keratin K73 (K6irs3) Polyclonal Antibody |
|---|---|
| Description | Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13. |
| Synonyms | KRT73, K6IRS3, IRT6IRS3, KRT6IRS3 |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human keratin K73 (formerly alsodesignated K6irs3; YSMLPGGCVTG SGN), coupled to KLH |
| Specificity | The antiserum stains specifically the cuticle layer of the inner root sheath (irs) of the hair follicle. K73 is expressed earlier than K72. Although there is a considerable sequence homology of keratin K73 polypeptide to keratins K5 and K6, no crossreactivity was observed with Western blotting and immunofluorescence microscopy. |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Langbein L et al. (2006) J Invest Dermatol 126: 2377-2386 |
| Background | Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13. |
| Supplier | ARP |
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