| Product Name | Anti-KRT18 (AT2G3) |
|---|---|
| Description | Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments. Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as biomarkers. Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases. |
| Synonyms | Cell proliferation inducing gene 46 protein , Cell proliferation inducing protein 46, CK 18 , CYK18, Cytokeratin 18, Cytokeratin endo B, K18, Keratin 18, Keratin D, Keratin type I cytoskeletal 18, Kerd |
| Host | Mouse |
| Clone | AT2G3. Anti-human KRT18 mAb, clone AT2G3, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KRT18 protein. |
| Immunogen | Recombinant human KRT18 (79-430aa) purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, IHC, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Moll, R, et al,. (1988) Am. J. Pathol., 132: 123-44 Schlimok, G, et al,. (1988) Arzneimittel-Forschung, 38: 435-7 Debus, E, et al,. (1984) Am. J. Pathol., 114: 121-30 (1984) |
| Supplier | ARP |
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