| Product Name | Anti-KRT8 (clone AT3D11) |
|---|---|
| Description | Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. |
| Synonyms | Keratin, type II cytoskeletal 8, keratin 8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO |
| Host | Mouse |
| Clone | AT3D11. Anti-human KRT8 mAb, clone AT3D11, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KRT8 protein. |
| Immunogen | Recombinant human KRT8 (1-483aa) purified from E. coli |
| Isotype | K,IgG3 |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Moriya, T ., et al. (2006) Med Mol Morphol 39(1): 8-13Leitner, A., et al. (2012) Biophys J 18;103(2): 195-201 |
| Supplier | ARP |
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