Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16, Monoclonal Antibody
| Product Name | Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16, Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels._Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. |
| Synonyms | Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPM594 |
| Immunogen | Recombinant human CDH16 protein |
| Isotype | IgG1, kappa |
| Reactivity | Canine, Human, Mouse, Rabbit, Rat |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 1014 |
| Uniprot | O75309 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Shen, S.S., et al. 2005. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 18: 933-40.Mazal, P.R., et al. 2005. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 36: 22-28. |
| Supplier | ARP |
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