Anti-La (SS-B) Protein (Human autoantigen) Monoclonal Antibody
| Product Name | Anti-La (SS-B) Protein (Human autoantigen) Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Mouse monoclonal antibody to La (SS-B) Protein |
| Synonyms | La, LARP3 |
| Clonality | Monoclonal |
| Clone | La4B6 |
| Immunogen | Recombinant La protein |
| Isotype | IgG1 |
| Specificity | The monoclonal antibody reacts specifically with the La antigen from a variety of mammals. It does not precipitate La-containing ribonucleoproteins. The antibody has been obtained by immunization of mice with recombinant La (SS-B) protein. |
| Reactivity | Bovine, Human, Mouse, Rat |
| Applications | IF, IP, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | 1. Manual of Biological Markers of Disease (1993) Section A (Eds. W.J. van Venrooij & R.N. Maini), Kluwer Acad. Publ. Dordrecht2. Manual of Biological Markers of Disease (1994), Section B-4.1 (Eds. W.J. van Venrooij & R.N. Maini), Kluwer Acad. Publ. Dordrecht 3. Troster, H. et al. (1995) J Autoimmun. 8: 825-842 |
| Background | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. |
| Supplier | ARP |
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