Anti-LIME (mouse) Polyclonall Antibody

Category: Antibodies
Catalog
11-408-C100
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Product Name Anti-LIME (mouse) Polyclonall Antibody
Description LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
Clone Polyclonal
Immunogen Bacterially expressed recombinant fragment (amino acids 86-202) of mouse LIME with C-terminal His-tag
Specificity The polyclonal antibody reacts with the cytoplasmic domain of mouse LIME (Lck-interacting molecule), a transmembrane adaptor protein involved in regulation of T cell activation by coreceptors.
Reactivity Mouse
Applications IP, WB
Form Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store at 2-8°C. Do not freeze.
Supplier Exbio

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