Anti-Lung Resistance-related Protein (LRP) Monoclonal Antibody
| Product Name | Anti-Lung Resistance-related Protein (LRP) Monoclonal Antibody |
|---|---|
| Description | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. Mouse monoclonal antibody to Human Lung Resistance-related Protein (LRP) |
| Synonyms | LRP, VAULT1 |
| Clonality | Monoclonal |
| Clone | LRP-56 |
| Immunogen | Human Lung Resistance-related Protein (LRP) |
| Isotype | IgG2b |
| Specificity | Mab LRP-56 reacts with an internal epitope of LRP (P110), which strongly overexpressed in various human non-P-glycoprotein multidrug-resistance (MDR) tumor cell lines. Not applicable in immunoblotting |
| Reactivity | Human |
| Applications | IHC |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Scheper, RJ. et al. (1994) Proc. Am Ass Can Res 35: 344Scheper, RJ. et al. (1993) Cancer Res. 53: 1475-1479Izquierdo et al. Am. J. Pathol. 148: 877-887 |
| Background | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. |
| Supplier | ARP |
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