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|Product Name||Anti-MAPK1 (AT1A4)|
|Description||Mitogen-activated protein kinases (MAPKs) are reported to be critical regulatory factors for the growth andmigration of various cell types including vascular smooth muscle cells (VSMCs). It has also been reported that the activation of the MAP kinase family, extracellular signal regulated kinases 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) via Src activation is important for AII-induced migration of VSMCs. MAPKs are intracellular signal-transduction pathways that have been shown to play a central role in the development of injury following ischemia in the brain and heart. MAPKs regulate gene expression, which is important in cell injury/repair and proliferation/differentiation.|
|Applications||Dot blot, ELISA, IF, WB|
|Clone||AT1A4. Anti-human MAPK1 mAb, clone AT1A4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MAPK1 protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide|
|Immunogen||Recombinant human MAPK1 (1-360) purified from E.coli|
|References||Le A, et al. (2010) Proc Natl Acad Sci U S A, 107(5):2037-42. Gesslein B, et al. (2010) Mol Vis,16:392-407. Lai EW, et al. (2004) J Invest Surg, 17:45-53.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||ERK, ERK2, ERT1, MAPK2, p38, p40, p41, p41mapk, P42MAPK, PRKM1, PRKM2, Mitogen-activated protein kinase 1 MAP kinase 2, MAPK 2, ERK 2, Extracellular Signal Regulated Kinase 2, MAPK 1.|
|Working Dilutions||Optimal dilution should be performed by user.|
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