| Product Name | Anti-MAPK3 (AT1A2) |
|---|---|
| Description | Mitogen-activated protein kinase (MAPKs) are a widely conserved family of serine/threonine kinase involved in many cellular programs such as cell proliferation, differentiation, motility, and death. MAPK3 (ERK1) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is on important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. |
| Synonyms | ERK1, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, MAP kinase3, Mitogen-activated protein kinase 3 |
| Host | Mouse |
| Clone | AT1A2. Anti-human MAPK3 mAb, clone AT1A2, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MAPK3 protein. |
| Immunogen | Recombinant human MAPK3 protein (1-137aa) purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Meloche S, et al,. Oncogene (2007) 26:3227-39 Raman M, et al,. Oncogene (2007) 26:3100-12 Roberts PJ, et al,. Oncogene (2007) 26:3291-310 Shaul YD, et al,. Seger R. Acta (2007) 1773:1213-26 |
| Supplier | ARP |
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