Anti-Melanoma Marker (MART-1 + gp100 + Tyrosinase), Monoclonal Antibody
| Product Name | Anti-Melanoma Marker (MART-1 + gp100 + Tyrosinase), Monoclonal Antibody |
|---|---|
| Description | This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation. |
| Synonyms | Melanoma antigen recognized by T-cells 1 (MART-1), MLAN-A, TYR, PMEL17 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | M2-7C10 + M2-9E3 + HMB45 + T311 |
| Immunogen | Recombinant hMART-1 protein (M2-7C10; M2-9E3); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45) |
| Isotype | IgG1, IgG2a & IgG2b, kappa |
| Reactivity | Human |
| Applications | IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 2315-MART-1; 7299-Tyrosinase; 6490-gp100 |
| Uniprot | Q16655-MART-1; P14679-Tyrosinase; P40967-gp100 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Chen Y-T, et. al. Proc Natl Acad Sci, USA, 1996, 93:5915-19.Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129.Gown AM, et. al. American Journal of Pathology, 1986, 123(2):195-203 |
| Supplier | ARP |
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