| Product Name | Anti-MEMO1 (clone AT1E9) |
|---|---|
| Description | MEMO1 (Mediator of ErbB2-driven cell motility 1) is a 297 amino acid protein. It is thought to relax extracellular chemotactic signals that are targeted at the microtubule cytoskeleton, thereby controlling cell migration. Additionally, MEMO1 is required for breast carcinoma migration, suggesting an important role in tumorigenesis. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity |
| Synonyms | Protein MEMO1, C2orf4, CGI-27, MEMO, NS5ATP7 |
| Host | Mouse |
| Clone | AT1E9. Anti-human MEMO1 mAb, clone AT1E9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MEMO1 protein. |
| Immunogen | Recombinant human MEMO1 (1-297aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Marone R., et al. (2004) Nat Cell Biol 6(6):515-522Meira M., et al. (2009) J Cell Sci 122:787-797Zaoui K., et al. (2010) Proc Natl Acad Sci USA 107(43):18517-18522 |
| Supplier | ARP |
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