Anti-Mouse CD126 (IL-6R) Monoclonal Antibody (Biotin conjugated)
| Product Name | Anti-Mouse CD126 (IL-6R) Monoclonal Antibody (Biotin conjugated) |
|---|---|
| Description | CD126 is an 80 kD IL-6 receptor _ chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor _ chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The _ chain (gp130, CD130) does not bind IL-6 by itself, but associates with the _-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The D7715A7 (15A7) antibody blocks IL-6/IL-6 receptor interactions. |
| Synonyms | IL-6R |
| Host | Rat |
| Clone | 15A7 |
| Isotype | Rat IgG2b |
| Reactivity | Mouse |
| Applications | FCM |
| Form | PBS with 0.09% NaN3, 0.2% BSA, PH7.2 |
| Background | CD126 is an 80 kD IL-6 receptor _ chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor _ chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The _ chain (gp130, CD130) does not bind IL-6 by itself, but associates with the _-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The D7715A7 (15A7) antibody blocks IL-6/IL-6 receptor interactions. |
| Supplier | Elabscience |
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