| Product Name | Anti-Mouse CD273 Monoclonal Antibody (FITC conjugated) |
|---|---|
| Description | CD273 is also called programmed death ligand 2 (PD-L2),also known as B7-DC. It has recently been clustered as CD273. This ligand is a 42 kD member of the immunoglobulin receptor superfamily expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse. |
| Synonyms | PD-L2 |
| Host | Rat |
| Clone | TY25 |
| Isotype | Rat IgG2a |
| Reactivity | Mouse |
| Applications | FCM |
| Form | PBS with 0.09% NaN3, 0.2% BSA, PH7.2 |
| Background | CD273 is also called programmed death ligand 2 (PD-L2),also known as B7-DC. It has recently been clustered as CD273. This ligand is a 42 kD member of the immunoglobulin receptor superfamily expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse. |
| Supplier | Elabscience |
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