| Product Name | Anti-Mouse CD314 Monoclonal Antibody (Biotin conjugated) |
|---|---|
| Description | NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, _/_ T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-_, GM-CSF, TNF-_, MIP1_ and others) and granzyme release from NK cells. |
| Synonyms | NKG2D |
| Host | Hamster |
| Clone | HMG2D |
| Isotype | Hamster IgG |
| Reactivity | Mouse |
| Applications | FCM |
| Form | PBS with 0.09% NaN3, 0.2% BSA, PH7.2 |
| Background | NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, _/_ T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-_, GM-CSF, TNF-_, MIP1_ and others) and granzyme release from NK cells. |
| Supplier | Elabscience |
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