Anti-MUC1 / EMA / CD227 (Epithelial Marker), Monoclonal Antibody
| Product Name | Anti-MUC1 / EMA / CD227 (Epithelial Marker), Monoclonal Antibody |
|---|---|
| Description | In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. This protein is proteolytically cleaved into α and β subunits that form a heterodimeric complex. The N-terminal α subunit and the C-terminal β subunit. . The α subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The β subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver. |
| Synonyms | Breast carcinoma-associated antigen DF3, CA15-3, Carcinoma-associated mucin Episialin, Epithelial Membrane Antigen, H23AG, KL-6, MAM6, MUC-1, MUC-1/SEC, MUC-1/X, MUC1-alpha, MUC1-beta, MUC1-CT, MUC1-NT, MUC1/ZD, Mucin 1 cell surface associated, Mucin-1 subunit beta, Peanut-reactive urinary mucin, PEM, PEMT, Polymorphic epithelial mucin, PUM, Tumor-associated epithelial membrane antigen, Tumor-associated mucin |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPM533 |
| Immunogen | Delipidated extract of human milk fat globule membranes |
| Isotype | IgG2a, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4582 |
| Uniprot | P15941 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Cordell J et al. 1985. Br J Cancer 52(3):347-54. Heyderman E et al. 1985. Br J Cancer 52(3):355-61 |
| Supplier | ARP |
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