| Product Name | Anti-MUC6 (Mucin 6 / Gastric Mucin), Monoclonal Antibody |
|---|---|
| Description | The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation. |
| Synonyms | Gastric mucin 6, MUC6, MUC6 mucin, Mucin 6 oligomeric mucus/gel forming, Mucin glycoprotein Fragment, Mucin-6, Secretory mucin MUC6 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MUC6/916 |
| Immunogen | Recombinant human MUC6 protein |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4588 |
| Uniprot | Q6W4X9 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Bartman A E, Buisine M P, Aubert J P, et al.. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues. J. Pathol. 186(4):398-405 (1998). |
| Supplier | ARP |
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